Mechanistic Modeling of Biochemical Systems Without a Priori Parameter Values Using the Design Space Toolbox v.3.0
نویسندگان
چکیده
منابع مشابه
Modeling Parameter Space Behavior of Vision Systems Using Bayesian Networks
The performance of most vision systems (or subsystems) is significantly dependent on the choice of its various parameters or thresholds. The associated parameter search space is extremely large and nonsmooth; moreover, the optimal choices of the parameters are usually mutually dependent on each other. In this paper we offer a Bayesian network-based probabilistic formalism, which we call the par...
متن کاملinvestigating the feasibility of a proposed model for geometric design of deployable arch structures
deployable scissor type structures are composed of the so-called scissor-like elements (sles), which are connected to each other at an intermediate point through a pivotal connection and allow them to be folded into a compact bundle for storage or transport. several sles are connected to each other in order to form units with regular polygonal plan views. the sides and radii of the polygons are...
Parameter Space Design of Robust Control Systems
Find a state or output feedbac:k wlth flxed gains such that nlce stabllity (deflned by a regloo in tbe elgenvalue plane) ls robust wlth respect to !arge plant parameter varladoos, semor failures, and quantlzatJon effects in tbe controller. Keep tbe requlred magnltude of control Inputs smail in thls deslgn. A tool for tacldJ.ng suc:h problems by des1gB in tbe controller parameter space % ls intr...
متن کاملLASSIM—A network inference toolbox for genome-wide mechanistic modeling
Recent technological advancements have made time-resolved, quantitative, multi-omics data available for many model systems, which could be integrated for systems pharmacokinetic use. Here, we present large-scale simulation modeling (LASSIM), which is a novel mathematical tool for performing large-scale inference using mechanistically defined ordinary differential equations (ODE) for gene regula...
متن کاملPhenotypes and tolerances in the design space of biochemical systems.
One of the major unsolved problems of modern biology is deep understanding of the complex relationship between the information encoded in the genome of an organism and the phenotypic properties manifested by that organism. Fundamental advances must be made before we can begin to approach the goal of predicting the phenotypic consequences of a given mutation or an organism's response to a novel ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: SSRN Electronic Journal
سال: 2020
ISSN: 1556-5068
DOI: 10.2139/ssrn.3542578